Key Timothy J, Allen Naomi, Appleby Paul, Overvad Kim, Tjønneland Anne, Miller Anthony, Boeing Heiner, Karalis Dimitrios, Psaltopoulou Theodora, Berrino Franco, Palli Domenico, Panico Salvatore, Tumino Rosario, Vineis Paolo, Bueno-De-Mesquita H B, Kiemeney Lambertus, Peeters Petra H M, Martinez Carmen, Dorronsoro Miren, González Carlos A, Chirlaque M D, Quiros J Ramon, Ardanaz Eva, Berglund Göran, Egevad Lars, Hallmans Göran, Stattin Pär, Bingham Sheila, Day Nicholas, Gann Peter, Kaaks Rudolf, Ferrari Pietro, Riboli Elio
Cancer Research U.K. Epidemiology Unit, University of Oxford, Oxford, United Kingdom.
Int J Cancer. 2004 Mar;109(1):119-24. doi: 10.1002/ijc.11671.
We examined the association between self-reported consumption of fruits and vegetables and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Data on food consumption and complete follow-up for cancer incidence were available for 130544 men in 7 countries recruited into EPIC between 1993 and 1999. After an average of 4.8 years of follow-up, there were 1104 incident cases of prostate cancer. The associations of consumption of total fruits, total vegetables, cruciferous vegetables and combined total fruits and vegetables with prostate cancer risk were examined using Cox regression, stratified for recruitment center and adjusted for height, weight and energy intake. There was a wide range in consumption of fruits and vegetables: mean intakes (g/day) in the bottom and top fifths of the distribution, as estimated from 24-hr recalls in a subsample of participants, were 53.2 and 410.7 for fruits, 97.1 and 242.1 for vegetables and 169.0 and 633.7 for fruits and vegetables combined. No significant associations between fruit and vegetable consumption and prostate cancer risk were observed. Relative risks (95% confidence intervals) in the top fifth of the distribution of consumption, compared to the bottom fifth, were 1.06 (0.84-1.34) for total fruits, 1.00 (0.81-1.22) for total vegetables and 1.00 (0.79-1.26) for total fruits and vegetables combined; intake of cruciferous vegetables was not associated with risk. These results suggest that total consumption of fruits and vegetables is not associated with the risk for prostate cancer.
我们在欧洲癌症与营养前瞻性调查（EPIC）中研究了自我报告的水果和蔬菜摄入量与前列腺癌风险之间的关联。1993年至1999年期间，EPIC在7个国家招募了130544名男性，他们提供了食物消费数据并对癌症发病率进行了完整随访。经过平均4.8年的随访，共出现1104例前列腺癌新发病例。使用Cox回归分析了总水果、总蔬菜、十字花科蔬菜以及水果和蔬菜总量的摄入量与前列腺癌风险之间的关联，并按招募中心进行分层，同时对身高、体重和能量摄入进行了调整。水果和蔬菜的摄入量差异很大：根据参与者子样本的24小时回忆估计，摄入量分布底部和顶部五分之一的平均摄入量（克/天），水果分别为53.2和410.7，蔬菜分别为97.1和242.1，水果和蔬菜总量分别为169.0和633.7。未观察到水果和蔬菜摄入量与前列腺癌风险之间存在显著关联。与摄入量分布底部五分之一相比，摄入量分布顶部五分之一的相对风险（95%置信区间），总水果为1.06（0.84 - 1.34），总蔬菜为1.00（0.81 - 1.22），水果和蔬菜总量为1.00（0.79 - 1.26）；十字花科蔬菜的摄入量与风险无关。这些结果表明，水果和蔬菜的总摄入量与前列腺癌风险无关。
