通过基于途径选择性表型的筛选鉴定有效的Ras信号抑制剂。 - Suppr

Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening.

作者信息

Müller Oliver, Gourzoulidou Eleni, Carpintero Mercedes, Karaguni Ioanna-Maria, Langerak Anette, Herrmann Christian, Möröy Tarik, Klein-Hitpass Ludger, Waldmann Herbert

机构信息

Max-Planck-Institut für molekulare Physiologie, Abteilung Strukturelle Biologie, Dortmund, Germany.

出版信息

Angew Chem Int Ed Engl. 2004 Jan 16;43(4):450-4. doi: 10.1002/anie.200352587.

DOI:10.1002/anie.200352587

PMID:14735532

Abstract

摘要

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Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening.通过基于途径选择性表型的筛选鉴定有效的Ras信号抑制剂。

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Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway.舒林酸衍生的Ras通路抑制剂作用于Ras-Raf相互作用以及Ras通路中的下游效应分子。

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Multiple aspects of the phenotype of mammary epithelial cells transformed by expression of activated M-Ras depend on an autocrine mechanism mediated by hepatocyte growth factor/scatter factor.通过激活的M-Ras表达而转化的乳腺上皮细胞表型的多个方面取决于由肝细胞生长因子/分散因子介导的自分泌机制。

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Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening.

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