通过基于途径选择性表型的筛选鉴定有效的Ras信号抑制剂。 - Suppr

Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening.

作者信息

Müller Oliver, Gourzoulidou Eleni, Carpintero Mercedes, Karaguni Ioanna-Maria, Langerak Anette, Herrmann Christian, Möröy Tarik, Klein-Hitpass Ludger, Waldmann Herbert

机构信息

Max-Planck-Institut für molekulare Physiologie, Abteilung Strukturelle Biologie, Dortmund, Germany.

出版信息

Angew Chem Int Ed Engl. 2004 Jan 16;43(4):450-4. doi: 10.1002/anie.200352587.

DOI:10.1002/anie.200352587

PMID:14735532

Abstract

摘要

相似文献

Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening.通过基于途径选择性表型的筛选鉴定有效的Ras信号抑制剂。

Angew Chem Int Ed Engl. 2004 Jan 16;43(4):450-4. doi: 10.1002/anie.200352587.

Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway.舒林酸衍生的Ras通路抑制剂作用于Ras-Raf相互作用以及Ras通路中的下游效应分子。

Angew Chem Int Ed Engl. 2004 Jan 16;43(4):454-8. doi: 10.1002/anie.200353089.

The new sulindac derivative IND 12 reverses Ras-induced cell transformation.新型舒林酸衍生物IND 12可逆转Ras诱导的细胞转化。

Cancer Res. 2002 Mar 15;62(6):1718-23.

Influence of K-ras activation on the survival responses of Caco-2 cells to the chemopreventive agents sulindac and difluoromethylornithine.K-ras激活对Caco-2细胞对化学预防剂舒林酸和二氟甲基鸟氨酸存活反应的影响。

Cancer Epidemiol Biomarkers Prev. 2000 Nov;9(11):1155-62.

Nitrosulindac (NCX 1102): a new nitric oxide-donating non-steroidal anti-inflammatory drug (NO-NSAID), inhibits proliferation and induces apoptosis in human prostatic epithelial cell lines.亚硝基舒林酸（NCX 1102）：一种新型的一氧化氮供体型非甾体抗炎药（NO-NSAID），可抑制人前列腺上皮细胞系的增殖并诱导其凋亡。

Prostate. 2004 Oct 1;61(2):132-41. doi: 10.1002/pros.20081.

Survivin is a downstream target and effector of sulindac-sensitive oncogenic Stat3 signalling in head and neck cancer.生存素是头颈癌中舒林酸敏感的致癌性信号转导和转录激活因子3（Stat3）信号通路的下游靶点及效应分子。

Int J Oral Maxillofac Surg. 2007 Jul;36(7):632-9. doi: 10.1016/j.ijom.2007.04.003. Epub 2007 Jun 12.

Phosphatidylinositol 3-kinase (PI-3K)/Akt but not PI-3K/p70 S6 kinase signaling mediates IGF-1-promoted lens epithelial cell survival.磷脂酰肌醇3激酶（PI-3K）/Akt信号通路而非PI-3K/p70 S6激酶信号通路介导胰岛素样生长因子-1（IGF-1）促进晶状体上皮细胞存活。

Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3577-88. doi: 10.1167/iovs.04-0279.

Apoptosis of mink lung epithelial cells by co-treatment of low-dose staurosporine and transforming growth factor-beta1 depends on the enhanced TGF-beta signaling and requires the decreased phosphorylation of PKB/Akt.低剂量星形孢菌素与转化生长因子-β1联合处理诱导水貂肺上皮细胞凋亡，依赖于增强的TGF-β信号传导，且需要蛋白激酶B/蛋白激酶B（PKB/Akt）磷酸化水平降低。

Biochem Biophys Res Commun. 2005 Mar 25;328(4):1170-81. doi: 10.1016/j.bbrc.2005.01.078.

A K-ras oncogene increases resistance to sulindac-induced apoptosis in rat enterocytes.K-ras癌基因可增强大鼠肠上皮细胞对舒林酸诱导凋亡的抗性。

Gastroenterology. 1997 Dec;113(6):1892-900. doi: 10.1016/s0016-5085(97)70008-8.

Multiple aspects of the phenotype of mammary epithelial cells transformed by expression of activated M-Ras depend on an autocrine mechanism mediated by hepatocyte growth factor/scatter factor.通过激活的M-Ras表达而转化的乳腺上皮细胞表型的多个方面取决于由肝细胞生长因子/分散因子介导的自分泌机制。

Mol Cancer Res. 2004 Apr;2(4):242-55.

引用本文的文献

Small molecule inhibitors of RAS proteins with oncogenic mutations.具有致癌突变的 RAS 蛋白的小分子抑制剂。

Cancer Metastasis Rev. 2020 Dec;39(4):1107-1126. doi: 10.1007/s10555-020-09911-9.

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design.直接靶向 KRAS 的小分子抑制剂：从结构见解到基于机制的设计。

Nat Rev Drug Discov. 2016 Nov;15(11):771-785. doi: 10.1038/nrd.2016.139. Epub 2016 Jul 29.

Therapeutic Approaches to RAS Mutation.RAS 突变的治疗方法。

Cancer J. 2016 May-Jun;22(3):165-74. doi: 10.1097/PPO.0000000000000187.

Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases.选择性非甾体抗炎药R-对映体对Rac1和Cdc42 GTP酶的新活性

PLoS One. 2015 Nov 11;10(11):e0142182. doi: 10.1371/journal.pone.0142182. eCollection 2015.

Enantioselective Synthesis of Spiroindenes by Enol-Directed Rhodium(III)-Catalyzed C-H Functionalization and Spiroannulation.通过烯醇导向的铑（III）催化的C-H官能化和螺环化反应对螺茚进行对映选择性合成。

Angew Chem Int Ed Engl. 2015 Nov 16;54(47):13975-9. doi: 10.1002/anie.201507029. Epub 2015 Sep 25.

Small-molecule modulation of Ras signaling.小分子调节 Ras 信号转导。

Nat Chem Biol. 2014 Aug;10(8):613-22. doi: 10.1038/nchembio.1560. Epub 2014 Jun 15.

Inhibition of Ras-Effector Interaction by Cyclic Peptides.环肽对Ras效应蛋白相互作用的抑制作用。

Medchemcomm. 2013 Feb 1;4(2):378-382. doi: 10.1039/C2MD20329D.

Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.β淀粉样蛋白 42 肽（Abeta42）降低化合物直接与 Abeta 结合，并干扰淀粉样前体蛋白（APP）跨膜二聚化。

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14597-602. doi: 10.1073/pnas.1003026107. Epub 2010 Aug 2.

Small-molecule inhibition of APT1 affects Ras localization and signaling.小分子抑制 APT1 会影响 Ras 的定位和信号转导。

Nat Chem Biol. 2010 Jun;6(6):449-56. doi: 10.1038/nchembio.362. Epub 2010 Apr 25.

Facile synthesis and preferred conformation analysis of cyclododeceno[b]indene.环十二烯并[B]茚的简便合成及优势构象分析。

Molecules. 2010 Feb 1;15(2):699-708. doi: 10.3390/molecules15020699.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

引用本文的文献