Barrios R H, Leyes M, Losada J I, Schweitzer D, Amillo S
Departamento de Cirugía Ortopédica y Traumatología, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra.
Rev Med Univ Navarra. 1995 Jan-Mar;39(1):14-20.
The authors review the literature, discuss clinical aspects and options in the management of desmoid tumors, analyze recent advances in the understanding of its biology and how they affect therapeutic choices, and outline future treatment perspectives. We conclude that although recurrence rates are high, wide excision is the best firs approach. If it is not possible, marginal surgery and radiation therapy can be performed. Radiation therapy can be also use in the attempt to control recurrent disease. Although many pharmacologic agents have been advocated there is no clear proof of their usefulness. Systemic therapy may be considered for selected patients that are not amenable to local treatment.
作者回顾了文献，讨论了韧带样瘤管理中的临床方面及选择，分析了在其生物学理解方面的最新进展以及这些进展如何影响治疗选择，并概述了未来的治疗前景。我们得出结论，尽管复发率很高，但广泛切除是最佳的首选方法。如果无法进行广泛切除，可以进行边缘手术和放射治疗。放射治疗也可用于控制复发性疾病。尽管已经提倡使用许多药物，但尚无明确证据证明其有效性。对于不适合局部治疗的特定患者，可以考虑全身治疗。
