犬基底动脉和大脑中动脉在正常和高二氧化碳张力下对血清素的异质性反应。
Heterogeneous responses of canine basilar and middle cerebral arteries to serotonin at normal and high CO2 tension.
作者信息
Tsukui A, Fukuda S, Shimoji K
机构信息
Department of Anesthesiology, Niigata University School of Medicine, Japan.
出版信息
Experientia. 1992 Dec 1;48(11-12):1118-21. doi: 10.1007/BF01948002.
The responses of basilar arteries (BAs) to serotonin were attenuated by high PCO2 (86 +/- 1 mm Hg) and the pH matched acidotic solution (PCO2 37 +/- 1 mm Hg), whereas the responses of middle cerebral arteries (MCAs) were not. High PCO2 decreased the basal tone of both arteries, and the changes in basal tone due to high PCO2 were not influenced by 3 x 10(-7) M imipramine, 10(-5) M pargyline or 10(-4) M aspirin. The responses of BAs to serotonin were attenuated by high PCO2 in the presence of imipramine, pargyline and aspirin. The responses of MCAs to serotonin were not influenced by high PCO2 in the presence of pargyline and aspirin, but attenuated by high PCO2 in the presence of imipramine.
高二氧化碳分压（86±1毫米汞柱）和pH值匹配的酸中毒溶液（二氧化碳分压37±1毫米汞柱）可减弱基底动脉（BA）对5-羟色胺的反应，而大脑中动脉（MCA）的反应则不受影响。高二氧化碳分压降低了两条动脉的基础张力，高二氧化碳分压引起的基础张力变化不受3×10⁻⁷M丙咪嗪、10⁻⁵M帕吉林或10⁻⁴M阿司匹林的影响。在丙咪嗪、帕吉林和阿司匹林存在的情况下，高二氧化碳分压可减弱BA对5-羟色胺的反应。在帕吉林和阿司匹林存在的情况下，MCA对5-羟色胺的反应不受高二氧化碳分压影响，但在丙咪嗪存在的情况下，高二氧化碳分压可使其反应减弱。
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