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The crystal structure of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveals a novel architecture for the bifunctional enzyme.

作者信息

O'Neil Robert H, Lilien Ryan H, Donald Bruce R, Stroud Robert M, Anderson Amy C

机构信息

Department of Chemistry, Dartmouth College, Burke Laboratories, Hanover, NH 03755, USA.

出版信息

J Eukaryot Microbiol. 2003;50 Suppl:555-6. doi: 10.1111/j.1550-7408.2003.tb00627.x.

DOI:10.1111/j.1550-7408.2003.tb00627.x
PMID:14736160
Abstract
摘要

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5
Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein-ligand interactions including a structural basis for observed antifolate resistance.来自人隐孢子虫的二氢叶酸还原酶-胸苷酸合酶的两种晶体结构揭示了蛋白质-配体相互作用，包括观察到的抗叶酸耐药性的结构基础。
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