Jaramillo Diego, Villegas-Medina Olga L, Doty David K, Rivas Roberto, Strife Katherine, Dwek Jerry R, Mulkern Robert V, Shapiro Frederic
Department of Radiology, Harvard Medical School and Massachusetts General Hospital, 32 Fruit St, Boston, MA 02114, USA.
AJR Am J Roentgenol. 2004 Feb;182(2):353-60. doi: 10.2214/ajr.182.2.1820353.
We sought to study the normal enhancement patterns seen on MRIs of the epiphysis, physis, and metaphysis and age-related vascular changes in piglets using gadoteridol, a nonionic gadolinium chelate.
We quantitatively and qualitatively analyzed the normal changes on sequential T1-weighted images after the IV administration of gadoteridol. In an investigation approved by the research animal care committee at our hospital, we studied the proximal and distal femurs of 26 piglets 1-6 weeks old and correlated the enhanced images with findings on intermediate-weighted, T2-weighted, and gradient-recalled echo images and at histologic examination.
We observed early enhancement of the epiphyseal vascular canals, the main physis, the physis of the secondary ossification center, and a metaphyseal band adjacent to the physis. Enhancement of the epiphyseal and metaphyseal marrow and of the epiphyseal cartilage was slower. In the epiphyseal cartilage, we saw three phases of enhancement: vascular, canalicular, and cartilaginous. As the piglets matured, enhancement of the epiphyseal cartilage decreased, and the epiphyseal vascular canals were less conspicuous. Physeal enhancement was greatest during the first week of life, declined at 3 weeks, and subsequently increased again as the physis came to lie adjacent to a larger segment of the epiphyseal ossification center.
Gadoteridol-enhanced MRIs showed multiple cartilaginous and vascular structures of the growing skeleton. With maturity and progressive epiphyseal ossification, epiphyseal cartilage enhancement decreased, and physeal cartilage enhancement increased.
我们试图利用非离子型钆螯合物钆特醇研究仔猪骨骺、生长板和干骺端MRI上的正常强化模式以及与年龄相关的血管变化。
我们对静脉注射钆特醇后连续的T1加权图像上的正常变化进行了定量和定性分析。在我院动物研究护理委员会批准的一项研究中，我们研究了26头1至6周龄仔猪的股骨近端和远端，并将增强图像与中等加权、T2加权和梯度回波图像上的表现以及组织学检查结果进行了关联。
我们观察到骨骺血管管、主要生长板、次级骨化中心的生长板以及与生长板相邻的干骺端带早期强化。骨骺和干骺端骨髓以及骨骺软骨的强化较慢。在骨骺软骨中，我们观察到三个强化阶段：血管性、小管性和软骨性。随着仔猪成熟，骨骺软骨的强化减弱，骨骺血管管不那么明显。生长板强化在出生后第一周最大，3周时下降，随后随着生长板靠近更大的骨骺骨化中心段而再次增加。
钆特醇增强MRI显示了生长中骨骼的多个软骨和血管结构。随着成熟和骨骺骨化的进展，骨骺软骨强化减弱，生长板软骨强化增加。
