Kadar Elissa, Rush John E, Wetmore Lois, Chan Daniel L
Department of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts 01536, USA.
J Am Anim Hosp Assoc. 2004 Jan-Feb;40(1):75-81. doi: 10.5326/0400075.
A 13-year-old dog was diagnosed with hypercalcemia of malignancy associated with adenocarcinoma of the anal sacs. Hypercalcemia was treated with intravenous (IV) 0.9% sodium chloride (NaCl), furosemide, calcitonin, and pamidronate. Hypomagnesemia was documented by 72 hours following a single, IV dose of pamidronate. The dog subsequently underwent surgery to remove the primary tumors, and multiple cardiac arrhythmias occurred during anesthesia. This case documents electrolyte abnormalities in a dog following treatment with pamidronate in conjunction with other therapies used to manage hypercalcemia. The authors postulate that hypomagnesemia may have contributed to the arrhythmias that occurred during anesthesia. Electrolyte abnormalities should be anticipated and corrected following pamidronate therapy in canine patients.
一只13岁的犬被诊断为与肛囊腺癌相关的恶性肿瘤高钙血症。高钙血症采用静脉注射0.9%氯化钠（NaCl）、呋塞米、降钙素和帕米膦酸盐进行治疗。在单次静脉注射帕米膦酸盐72小时后记录到低镁血症。这只犬随后接受了切除原发性肿瘤的手术，麻醉期间出现了多种心律失常。该病例记录了犬在使用帕米膦酸盐联合其他用于治疗高钙血症的疗法后出现的电解质异常。作者推测低镁血症可能是麻醉期间发生心律失常的原因。在犬类患者接受帕米膦酸盐治疗后，应预期并纠正电解质异常。
