Carcangiu M L, Chambers J T
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510.
Gynecol Oncol. 1992 Dec;47(3):298-305. doi: 10.1016/0090-8258(92)90130-b.
One hundred eight cases of uterine papillary serous carcinoma (UPSC) were analyzed to characterize its histologic features and biologic behavior. Special situations that could conceivably modify the behavior and therapeutic approaches were considered: (1) the occurrence of areas of endometrioid carcinoma in otherwise typical UPSC; (2) the confinement of UPSC to an otherwise benign endometrial polyp or the endometrial mucosa or absence of residual tumor at the time of hysterectomy; and (3) the coexistence of a superficial UPSC and a serous ovarian carcinoma. There was coexistence of endometrioid and UPSC in 22 cases, and tumor was confined to an endometrial polyp or endometrium in 19 cases. There was simultaneous pathologic stage I UPSC and papillary serous ovarian carcinoma in 10 cases. In patients with pathologic stages I and II UPSC the presence of areas of endometrioid carcinoma intermixed with the UPSC did not improve survival. Patients with stage I disease and no residual tumor or tumor confined to an endometrial polyp/endometrial mucosa and without vascular invasion had a survival not statistically different from those with stage I disease but with myometrial and/or vascular invasion. Patients with stage I UPSC with concomitant ovarian serous surface papillary carcinoma had survival not statistically different from patients with stage IV UPSC.
对108例子宫浆液性乳头状癌（UPSC）进行分析，以明确其组织学特征和生物学行为。研究考虑了可能改变其行为和治疗方法的特殊情况：（1）在典型UPSC中出现子宫内膜样癌区域；（2）UPSC局限于良性子宫内膜息肉或子宫内膜黏膜，或子宫切除时无残留肿瘤；（3）浅表性UPSC与浆液性卵巢癌并存。22例存在子宫内膜样癌与UPSC并存，19例肿瘤局限于子宫内膜息肉或子宫内膜。10例同时存在病理分期为I期的UPSC和浆液性乳头状卵巢癌。在病理分期为I期和II期的UPSC患者中，子宫内膜样癌区域与UPSC混合存在并不改善生存率。I期疾病且无残留肿瘤或肿瘤局限于子宫内膜息肉/子宫内膜黏膜且无血管侵犯的患者，其生存率与I期疾病但有肌层和/或血管侵犯的患者无统计学差异。I期UPSC合并卵巢浆液性表面乳头状癌的患者，其生存率与IV期UPSC患者无统计学差异。
