Sasaki Yoshihiro, Shukla Rameshwer, Smith Bradley D
Department of Chemistry and Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556-5670, USA.
Org Biomol Chem. 2004 Jan 21;2(2):214-9. doi: 10.1039/b314006g. Epub 2003 Dec 10.
Tris(2-aminoethyl)amine derivatives with appended urea and sulfonamide groups are shown to facilitate the translocation of fluorescent phospholipid probes and endogenous phosphatidylserine across vesicle and erythrocyte cell membranes. The synthetic translocases appear to operate by binding to the phospholipid head groups and forming lipophilic supramolecular complexes which diffuse through the non-polar interior of the bilayer membrane.
带有附加脲基和磺酰胺基的三（2-氨基乙基）胺衍生物被证明有助于荧光磷脂探针和内源性磷脂酰丝氨酸跨囊泡和红细胞细胞膜的转运。这些合成的转位酶似乎是通过与磷脂头部基团结合并形成亲脂性超分子复合物来发挥作用的，这些复合物会扩散穿过双层膜的非极性内部。
