Khidekel Nelly, Hsieh-Wilson Linda C
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Org Biomol Chem. 2004 Jan 7;2(1):1-7. doi: 10.1039/b312466e. Epub 2003 Dec 2.
Proteins undergo a remarkable variety of posttranslational modifications, with more than 200 distinct modifications identified to date. Increasing evidence suggests that many proteins bear multiple, distinct modifications, and the ability of one modification to antagonize or synergize the deposition of another can have significant biological consequences. Here, we illustrate the importance of posttranslational modifications within the context of transcriptional regulation, and we offer a perspective on the emerging role of combinatorial networks of modifications. Finally, we discuss the potential for chemical approaches to transform our understanding of the field.
蛋白质会经历各种各样显著的翻译后修饰，迄今为止已鉴定出200多种不同的修饰。越来越多的证据表明，许多蛋白质带有多种不同的修饰，一种修饰对另一种修饰的沉积产生拮抗或协同作用的能力可能会产生重大的生物学后果。在这里，我们阐述了翻译后修饰在转录调控背景下的重要性，并对修饰组合网络的新兴作用提出了一种观点。最后，我们讨论了化学方法改变我们对该领域理解的潜力。
