Keltner Norman L, Kelley Frances J
University of Alabama School of Nursing, Birmingham, AL, USA.
Perspect Psychiatr Care. 2003 Oct-Dec;39(4):169-73. doi: 10.1111/j.1744-6163.2003.00169.x.
The forgoing represents an attempt to reduce psychopharmacology to a presynaptic neuron-synapse-post-synaptic neuron event. Obviously other strategies might be employed resulting in equal or perhaps greater clarity. Limitations of this approach include the lack of discussion about neuronal modulation, second messenger systems (which most NTs discussed here use), expansion of the ion channel discussion, and the implications of excitatory vs. inhibitory physiological effects. Nonetheless, we find this template for understanding psychotropic drug mechanism of action a fruitful lens through which to guide further study of these drugs. We feel like we are moving toward a silver dollar-size circle.
上述内容试图将精神药理学简化为一个从突触前神经元到突触再到突触后神经元的过程。显然，也可以采用其他策略，可能会带来同等或更高的清晰度。这种方法的局限性包括缺乏对神经元调节、第二信使系统（本文讨论的大多数神经递质都使用该系统）的讨论，离子通道讨论的扩展，以及兴奋与抑制生理效应的影响。尽管如此，我们发现这个理解精神药物作用机制的模板是一个富有成效的视角，可用于指导对这些药物的进一步研究。我们感觉自己正朝着一个银元大小的圆圈迈进。
