Horiuchi Masatsugu
First Department of Medical Biochemistry, Ehime University School of Medicine.
Nihon Rinsho. 2004 Jan;62(1):29-36.
The peptide angiotensin(Ang) II exerts hemodynamic, and renal as well as cardiovascular structural effects. Multiple lines of evidence have suggested the existence of several Ang II receptor subtypes. Recent evidence has revealed that the functions of the AT1 and AT2 receptors are mutually antagonistic in various cells and tissues. The effect of AT1 blocker(ARB) may not be entirely due to the blockade of the AT1 receptor. When AT1 receptor is blocked and unbound Ang II may act on AT2 receptor and Ang 1-7 and Ang IV via AT4 receptor might be involved in the effects of ARB. If the AT2 receptor contributes to the pathogenesis and consequent remodeling of cardiovascular diseases in human, ARB may have some specific effects in the treatment of cardiovascular diseases. A more extensive knowledge of the AT2 receptor could therefore contribute to the understanding of the clinical beneficial effects of ARB.
血管紧张素（Ang）II 具有血流动力学、肾脏以及心血管结构方面的作用。多条证据表明存在几种血管紧张素 II 受体亚型。最近的证据显示，在各种细胞和组织中，AT1 和 AT2 受体的功能相互拮抗。AT1 受体阻滞剂（ARB）的作用可能并不完全归因于对 AT1 受体的阻断。当 AT1 受体被阻断且未结合的血管紧张素 II 可能作用于 AT2 受体时，血管紧张素 1-7 和血管紧张素 IV 可能通过 AT4 受体参与 ARB 的作用。如果 AT2 受体在人类心血管疾病的发病机制及随后的重塑过程中起作用，那么 ARB 在心血管疾病的治疗中可能具有一些特定作用。因此，对 AT2 受体更广泛的了解有助于理解 ARB 的临床有益作用。
