Wakino Shu
Department of Emergency Medicine, School of Medicine, Keio University.
Nihon Rinsho. 2004 Jan;62(1):180-6.
Peroxisome proliferator-activated receptor gamma(PPAR gamma) belongs to a nuclear receptor super family which is activated by insulin sensitizer, thiazolidinediones. The expression of PPAR gamma was detected in the vascular tissues and PPAR gamma ligands have various effects on all cells which constitute the vasculature including endothelial cells, vascular smooth muscle cells and monocytes/macrophages. The net effect by PPAR gamma ligands is proven to be anti-atherosclerosis. In various atherosclerogenic mouse models and balloon injury model, PPAR gamma ligands attenuate atherosclerotic lesion formation and intimal hyperplasia. In human study, various beneficial effects by PPAR gamma ligands were reported in terms of atherogenesis. PPAR gamma ligands attenuate the increase in intima-media thickness in diabetic patients. However, long-term effects remain to be seen.
过氧化物酶体增殖物激活受体γ（PPARγ）属于核受体超家族，可被胰岛素增敏剂噻唑烷二酮激活。在血管组织中检测到PPARγ的表达，PPARγ配体对构成脉管系统的所有细胞（包括内皮细胞、血管平滑肌细胞和单核细胞/巨噬细胞）具有多种作用。PPARγ配体的净效应被证明具有抗动脉粥样硬化作用。在各种动脉粥样硬化小鼠模型和球囊损伤模型中，PPARγ配体可减轻动脉粥样硬化病变形成和内膜增生。在人体研究中，据报道PPARγ配体在动脉粥样硬化发生方面具有多种有益作用。PPARγ配体可减轻糖尿病患者内膜中层厚度的增加。然而，长期影响仍有待观察。
