Garg K, Khanna S K, Das M, Singh G B
Dyes and Food Adulterant Toxicology Laboratory, Industrial Toxicology Research Centre, Lucknow, India.
Food Chem Toxicol. 1992 Nov;30(11):967-71. doi: 10.1016/0278-6915(92)90182-k.
The bio-elimination and organ retention of orally administered [14C]benzanthrone, an anthraquinone dye intermediate, were determined in control and ascorbic acid-supplemented guinea pigs. Urinary excretion of benzanthrone in control and ascorbic acid-treated animals during 96 hr was 27.9 and 30.5%, respectively, with peak elimination at 48 hr. Faecal elimination in control and supplemented animals during 96 hr was 24.5 and 38.8%, respectively, with a peak at 48 hr. The organ retention of radiolabelled benzanthrone at the end of 96 hr was of the order of 39% in control animals (gastro-intestinal tract 16%; liver 22%; testis 1.2%); ascorbic acid supplementation reduced benzanthrone retention to 19.5% (gastro-intestinal tract 12.7%; liver 6.8%). Overall, pretreatment of guinea pigs with ascorbic acid caused a 32% enhancement in the clearance of radiolabelled benzanthrone through the urine and faeces, while organ retention was reduced by about 50%. A prophylactic dose of ascorbic acid may prevent benzanthrone-induced toxic symptoms in exposed workers.
在对照豚鼠和补充了抗坏血酸的豚鼠中，测定了口服蒽醌染料中间体[14C]苯并蒽酮的生物消除和器官留存情况。在96小时内，对照动物和经抗坏血酸处理的动物中苯并蒽酮的尿排泄率分别为27.9%和30.5%，在48小时时消除达到峰值。在96小时内，对照动物和补充了抗坏血酸的动物中苯并蒽酮的粪便消除率分别为24.5%和38.8%，在48小时时达到峰值。在96小时结束时，对照动物中放射性标记的苯并蒽酮在器官中的留存率约为39%（胃肠道16%；肝脏22%；睾丸1.2%）；补充抗坏血酸后，苯并蒽酮的留存率降至19.5%（胃肠道12.7%；肝脏6.8%）。总体而言，用抗坏血酸预处理豚鼠可使放射性标记的苯并蒽酮通过尿液和粪便的清除率提高32%，而器官留存率降低约50%。预防性剂量的抗坏血酸可能预防接触苯并蒽酮的工人出现中毒症状。
