Connor S B, Quill T J, Jacobs J R
Department of Biomedical Engineering, Duke University, Durham, NC 27706.
IEEE Trans Biomed Eng. 1992 Sep;39(9):980-2. doi: 10.1109/10.256432.
Prototype systems implementing algorithms for automated drug infusions are typically constructed by coupling a microcomputer to a drug infusion pump through a serial communications interface. Infusion rates demanded of the infusion pump in many computed-controlled drug delivery applications are made to change at intervals much shorter than those encountered under routine clinical use. Because the ability of infusion pumps to maintain accurate flow rates during high frequency rate changes has not been documented, the purpose of this study was to validate the volumetric accuracy of three commercially available infusion pumps operating in a demanding computer-controlled application. In independent 2-h evaluations, the infusion rate demanded of each pump changed as often as every 5, 10, or 15 s using an algorithm for computer-controlled pharmacokinetic model-driven intravenous infusion. Accuracy of the infusion devices was determined gravimetrically. At all measurement times, each of the infusion pumps was accurate to within approximately +/- 5% of the expected volumetric output under each of the infusion rate intervals tested. Flow rate accuracy of +/- 5% is equal to the nominal expected accuracy of these infusion pumps in conventional clinical use.
实现自动药物输注算法的原型系统通常是通过串行通信接口将微型计算机与药物输注泵耦合构建而成。在许多计算机控制的药物输送应用中，对输注泵要求的输注速率变化间隔比常规临床使用时遇到的间隔要短得多。由于尚未记录输注泵在高频速率变化期间维持准确流速的能力，本研究的目的是验证在要求苛刻的计算机控制应用中运行的三种市售输注泵的容量准确性。在独立的2小时评估中，使用计算机控制的药代动力学模型驱动静脉输注算法，每个泵要求的输注速率每5、10或15秒变化一次。通过重量法确定输注装置的准确性。在所有测量时间，在每个测试的输注速率间隔下，每个输注泵的准确性在预期容量输出的约+/-5%范围内。+/-5%的流速准确性等同于这些输注泵在常规临床使用中的标称预期准确性。
