Kounami Shinji, Aoyagi Noriyuki, Nakayama Keiko, Yoshiyama Megumi, Boshi H, Sakiyama Michiyo, Takeuchi Takeshi, Yoshikawa Norishige
Department of Pediatrics, Wakayama Medical University, Kimiidera, Wakayama City, Japan.
Pediatr Transplant. 2003 Oct;7(5):400-3. doi: 10.1034/j.1399-3046.2003.00092.x.
We describe a 4-yr-old boy with an occult primitive neuroectodermal tumor, who suffered fatal PTE after a second course of HDC with autologous PBSCT. On day + 52 after a second PBSCT, he was admitted because of respiratory distress. Respiratory failure rapidly progressed and he died within 4 days. The diagnosis of PTE was confirmed by a lung perfusion study with technetium-99m macroaggregated albumin, but too late to allow treatment. Although rare, PTE must be recognized as an important differential diagnosis when respiratory symptoms are observed after HDC with PBSCT.
