冬凌草甲素和冬凌草素是草药补充剂PC SPES的成分冬凌草的抗血管生成活性的原因。
Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES.
作者信息
Meade-Tollin Linda C, Wijeratne E M Kithsiri, Cooper Deborah, Guild Mischa, Jon Edlyn, Fritz Anne, Zhou Guang-Xiong, Whitesell Luke, Liang Jing-Yu, Gunatilaka A A Leslie
机构信息
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E. Valencia Road, Tucson, AZ 85706-6800, USA.
出版信息
J Nat Prod. 2004 Jan;67(1):2-4. doi: 10.1021/np0304114.
Antiangiogenic activity has been identified in an aqueous EtOH extract of Rabdosia rubescens, a component of the dietary supplement PC SPES. Bioassay-guided fractionation using a novel in vitro human endothelial cell-based assay for angiogenesis afforded the diterpenoids ponicidin (1) and oridonin (2), with significant antiangiogenic activity at subcytotoxic concentrations, suggesting that these constituents may strongly contribute to the demonstrated clinical efficacy of PC SPES as a treatment for advanced prostate cancer.
在毛叶香茶菜（一种膳食补充剂PC SPES的成分）的乙醇水提取物中已鉴定出抗血管生成活性。使用一种基于人内皮细胞的新型体外血管生成检测方法进行生物测定指导的分级分离，得到了二萜类化合物ponicidin（1）和冬凌草甲素（2），它们在亚细胞毒性浓度下具有显著的抗血管生成活性，这表明这些成分可能对PC SPES作为晚期前列腺癌治疗药物所显示的临床疗效有很大贡献。
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