从浴液中去除钙对离体大鼠十二指肠收缩的影响。
Influence of calcium removal from bath solution on isolated rat duodenum contractions.
作者信息
Süer C, Erenmemisoglu A, Temocin S, Akar S, Beydagi H, Taspolat I
机构信息
Department of Physiology, Erciyes University, Medical Faculty, Kayser, Turkey.
出版信息
Indian J Physiol Pharmacol. 1992 Jul;36(3):181-4.
In this study whether extracellular Ca++ is essential to produce an increase of tension of isolated rat duodenum by ACh, 5-HT, AVP and KCl-, was examined. KCl- and AVP-evoked contractions were almost totally prevented by Ca++ removal from bath solution. The increase of tension of isolated duodenum caused by ACh or 5-HT was totally prevented after adding nifedipine, a Ca++ channel blocker, into Ca free solution. Our results suggest that ACh or 5-HT utilizes intracellular as well as extracellular sources of Ca++ to produce contraction in rat duodenum, whereas AVP-or KCl evoked contraction was mainly due to influx of Ca from extracellular sources.
在本研究中，检测了细胞外钙离子对于乙酰胆碱、5-羟色胺、血管加压素和氯化钾引起的离体大鼠十二指肠张力增加是否必不可少。从浴液中去除钙离子几乎完全抑制了氯化钾和血管加压素引起的收缩。在无钙溶液中加入钙离子通道阻滞剂硝苯地平后，乙酰胆碱或5-羟色胺引起的离体十二指肠张力增加被完全抑制。我们的结果表明，乙酰胆碱或5-羟色胺利用细胞内和细胞外的钙离子来源在大鼠十二指肠中产生收缩，而血管加压素或氯化钾引起的收缩主要是由于细胞外钙离子的内流。
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