Gelatt Kirk N, MacKay Edward O
Department of Small Animal Clinical Sciences and Gwathmey-Adams Laboratory for Vision Science, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610-0126, USA.
Vet Ophthalmol. 2004 Jan-Feb;7(1):53-7. doi: 10.1111/j.1463-5224.2004.00326.x.
To evaluate changes in intraocular pressure and pupil size in glaucomatous dogs after instillation of 0.004% travoprost once in the morning, or once in the evening, or twice daily in 5-day multiple dose studies.
Applanation tonometry (IOP) and pupil size (PS) measurements were obtained at 8 a.m., 10 a.m., 12 noon, 2 p.m. and 4 p.m. in eight glaucoma dogs. Methylcellulose (0.5% as placebo) was instilled in the control eye, and 0.004% travoprost was instilled in the opposite drug eye. Methylcellulose (0.5%) and 0.004% travoprost were instilled on the 2nd through to the 5th day with instillations in the morning (8.30 a.m.), or evening (8 p.m.), or twice daily (8.30 a.m. and 8 p.m.).
The mean +/- SEM diurnal changes from baseline IOP in the control and placebo eyes in all three studies ranged from 1.2 +/- 0.3 mmHg to 3.2 +/- 0.9 mmHg. The mean +/- SEM diurnal changes from the baseline IOP after 0.004% travoprost at 8 a.m. once daily for the next 4 days were 19.0 +/- 2.7 mmHg, 24.7 +/- 2.7 mmHg, 24.9 +/- 3.1 mmHg, and 24.7 +/- 3.1 mmHg, respectively, and were significantly different from the control eye. After travoprost was instilled at 8 p.m., the mean +/- SEM baseline changes from the baseline IOP in the drug eyes were 23.5 +/- 2.2 mmHg, 24.2 +/- 2.2 mmHg, 24.5 +/- 2.3 mmHg, and 24.2 +/- 2.3 mmHg, respectively. When 0.004% travoprost was instilled twice daily, the mean +/- SEM baseline IOP changes were 27.7 +/- 2.1 mmHg, 28.1 +/- 2.1 mmHg, 28.4 +/- 2.2 mmHg, and 28.5 +/- 2.2 mmHg, respectively, and were significantly different from the control eyes. Miosis of varying duration was frequent during the three studies.
Travoprost instilled once daily (a.m. or p.m.) as well as twice daily produces significant decreases in IOP and PS in the glaucomatous Beagle.
在为期5天的多剂量研究中，评估青光眼犬每天早晨、晚上或每日两次滴注0.004%曲伏前列素后眼压和瞳孔大小的变化。
对8只青光眼犬在上午8点、10点、中午12点、下午2点和4点进行眼压测量（IOP）和瞳孔大小（PS）测量。对照眼滴注甲基纤维素（0.5%作为安慰剂），对侧用药眼滴注0.004%曲伏前列素。在第2天至第5天滴注甲基纤维素（0.5%）和0.004%曲伏前列素，滴注时间为早晨（上午8:30）、晚上（晚上8点）或每日两次（上午8:30和晚上8点）。
在所有三项研究中，对照眼和安慰剂眼的眼压自基线的平均±标准误昼夜变化范围为1.2±0.3 mmHg至3.2±0.9 mmHg。在接下来4天每天上午8点滴注0.004%曲伏前列素后，眼压自基线的平均±标准误昼夜变化分别为19.0±2.7 mmHg、24.7±2.7 mmHg、24.9±3.1 mmHg和24.7±3.1 mmHg，与对照眼有显著差异。晚上8点滴注曲伏前列素后，用药眼眼压自基线的平均±标准误变化分别为23.5±2.2 mmHg、24.2±2.2 mmHg、24.5±2.3 mmHg和24.2±2.3 mmHg。当每日两次滴注0.004%曲伏前列素时，眼压自基线的平均±标准误变化分别为27.7±2.1 mmHg、28.1±2.1 mmHg、28.4±2.2 mmHg和28.5±2.2 mmHg，与对照眼有显著差异。在三项研究期间，不同持续时间的瞳孔缩小很常见。
在青光眼比格犬中，每天一次（上午或下午）以及每天两次滴注曲伏前列素均可使眼压和瞳孔大小显著降低。
