Sugendran K, Jeevaratnam K, Husain K, Singh R, Srivastava D K
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior.
Indian J Physiol Pharmacol. 1992 Jul;36(3):219-21.
Bis-2-Chloroethyl sulphide, commonly known as sulphur mustard (SM) or mustard gas, an alkylating agent, is frequently used as a chemical warfare agent. Inhibition of glycolysis has been related to skin injury and cell death. The effects of SM on tissue glycogen, blood glucose, lactate/pyruvate ratio were investigated in the present study. After a single dermal application of 1.0 LD50 SM in mice, a significant hyperglycemia was observed at 24 hr post exposure. There was a corresponding decrease in liver glycogen content, with no alteration in glycogen content of brain, muscles and kidney. Blood pyruvate and lactate levels were not appreciably altered.
双（2-氯乙基）硫醚，通常称为硫芥（SM）或芥子气，是一种烷化剂，常被用作化学战剂。糖酵解的抑制与皮肤损伤和细胞死亡有关。本研究调查了硫芥对组织糖原、血糖、乳酸/丙酮酸比值的影响。在小鼠单次经皮给予1.0半数致死剂量（LD50）的硫芥后，在暴露后24小时观察到显著的高血糖。肝脏糖原含量相应降低，而脑、肌肉和肾脏的糖原含量没有变化。血丙酮酸和乳酸水平没有明显改变。
