Verver Suzanne, Warren Robin M, Munch Zahn, Richardson Madalene, van der Spuy Gian D, Borgdorff Martien W, Behr Marcel A, Beyers Nulda, van Helden Paul D
Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.
Lancet. 2004 Jan 17;363(9404):212-4. doi: 10.1016/S0140-6736(03)15332-9.
The prevalence of infection among household contacts of people with tuberculosis is high. This information frequently guides active case finding. We analysed DNA fingerprints of Mycobacterium tuberculosis from 765 tuberculosis patients in Ravensmead and Uitsig, adjacent suburbs of Cape Town, South Africa. In 129 households in which DNA fingerprints were available for more than one patient, we identified 313 patients, of whom 145 (46%) had a fingerprint pattern matching that of another member of the household. The proportion of transmission in the community that took place in the household was 19%, and therefore, in this high-incidence area, tuberculosis transmission occurs mainly outside the household.
结核病患者家庭接触者中的感染率很高。这一信息常常指导主动病例发现工作。我们分析了来自南非开普敦相邻郊区雷文斯米德和尤伊西格的765名结核病患者的结核分枝杆菌DNA指纹。在129户有不止一名患者的DNA指纹可用的家庭中，我们识别出313名患者，其中145名（46%）的指纹图谱与家庭中的另一名成员相匹配。社区中发生在家庭内的传播比例为19%，因此，在这个高发病率地区，结核病传播主要发生在家庭之外。
