Thorburn A, Thorburn J, Frankel A E
Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, North Carolina 27157, USA.
Apoptosis. 2004 Jan;9(1):19-25. doi: 10.1023/B:APPT.0000012118.95548.88.
Targeted toxins are fusion proteins that combine a targeting molecule that selectively binds to and enters tumor cells with a protein toxin that kills the target cells. These molecules represent an exciting approach to develop effective cancer-specific therapeutics that have few side effects on normal tissues and numerous such toxins are in various stages of pre-clinical and clinical development to treat a wide variety of tumors. In this review, we discuss this strategy, describe ways that the toxins activate the apoptosis machinery and discuss future developments in this field.
靶向毒素是一种融合蛋白，它将一种能选择性结合并进入肿瘤细胞的靶向分子与一种可杀死靶细胞的蛋白毒素结合在一起。这些分子代表了一种开发有效癌症特异性疗法的令人兴奋的方法，这种疗法对正常组织几乎没有副作用，并且有许多此类毒素正处于临床前和临床开发的各个阶段，用于治疗多种肿瘤。在这篇综述中，我们讨论了这一策略，描述了毒素激活凋亡机制的方式，并探讨了该领域的未来发展。
