Wenger Galen R, Schmidt Cecilia, Davisson Muriel T
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Behav Genet. 2004 Jan;34(1):105-19. doi: 10.1023/B:BEGE.0000009480.79586.ee.
Ts65Dn and littermate controls were trained to respond (nose-poke) under operant schedules of reinforcement. A small difference was observed in the initial operant training of the Ts65Dn mouse that disappeared with training under a fixed-ratio 15 schedule of milk presentation. No difference was observed in a position reversal task in which mice initially trained to respond upon one photocell had to learn to respond on a previously inactive photocell. Under an incremental repeated acquisition of behavioral chains schedule, no difference was observed when one or two responses were required to complete the sequence. However, when three or four responses were required to complete the sequence, a marked deficit was observed in the Ts65Dn mice. These results show that both Ts65Dn and littermate controls can be trained to respond under operant schedules of reinforcement, but that Ts65Dn mice have a learning deficit that is correlated with task difficulty.
Ts65Dn小鼠及其同窝对照在操作性强化程序下接受反应（鼻触）训练。在Ts65Dn小鼠的初始操作性训练中观察到微小差异，但在固定比率15的牛奶呈现程序训练下该差异消失。在位置反转任务中未观察到差异，在该任务中，最初训练对一个光电管做出反应的小鼠必须学会对之前未激活的光电管做出反应。在行为链的增量重复习得程序下，当完成序列需要一或两个反应时未观察到差异。然而，当完成序列需要三或四个反应时，在Ts65Dn小鼠中观察到明显缺陷。这些结果表明，Ts65Dn小鼠及其同窝对照都可以在操作性强化程序下接受反应训练，但Ts65Dn小鼠存在与任务难度相关的学习缺陷。
