一种无机铁络合物，可抑制来自结核分枝杆菌的野生型和异烟肼耐药突变体2-反式烯酰基-ACP（CoA）还原酶。
An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis.
作者信息
Oliveira Jaim S, Sousa Eduardo H S, Basso Luiz A, Palaci Moisés, Dietze Reynaldo, Santos Diógenes S, Moreira Icaro S
机构信息
Universidade Federal do Rio Grande do Sul, Departamento de Biologia Molecular e Biotecnologia, Av. Bento Gonçalves 9500, Porto Alegre, RS 91501-970, Brazil.
出版信息
Chem Commun (Camb). 2004 Feb 7(3):312-3. doi: 10.1039/b313592f. Epub 2004 Jan 7.
The in vitro kinetics of inactivation of both wild-type and I21V InhA enzymes by [FeII(CN)5(INH)]3- indicate that this process requires no activation by KatG, and no need for the presence of NADH. This inorganic complex may represent a new class of lead compounds to the development of anti-tubercular agents aiming at inhibition of a validated target.
[FeII(CN)5(INH)]3-对野生型和I21V InhA酶的体外失活动力学表明，该过程无需KatG激活，也不需要NADH的存在。这种无机复合物可能代表了一类新型先导化合物，可用于开发旨在抑制有效靶点的抗结核药物。
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