[大鼠头颈部分次照射所致放射性涎腺炎的组织形态学及涎腺闪烁显像结果。一种评估潜在放射防护物质的模型]

[Histomorphologic and salivary gland scintigraphic findings in radiation-induced sialadenitis due to fractionated irradiation of the head and neck region of rats. A model for evaluating potentially radioprotective substances].

作者信息

Sagowski C, Wenzel S, Riehle I, Tesche S, Jenicke L, Zywietz F, Roeser K, Metternich F U

机构信息

Klinik und Poliklinik für Hals-, Nasen- und Ohrenheilkunde, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg.

出版信息

HNO. 2004 Jan;52(1):25-32. doi: 10.1007/s00106-003-0855-5.

DOI:10.1007/s00106-003-0855-5

PMID:14740111

Abstract

INTRODUCTION

The aim of this study was to correlate structural, histomorphological damage of the salivary gland with scintigraphic findings during fractioned radiotherapy.

METHODS

The head and neck area of 27 WAG/RijH rats was irradiated with (60)Co-gamma-rays (60 Gy/30f/6 weeks). A port-system was implanted and (99m)Tc-pertechnetat applied at different stages of irradiation (0, 16, 30, 46, 60 Gy and 6 months post irradiation).

RESULTS

After the application of 16 Gy an intra- and extra-cellular oedema developed in the salivary glands. The progressive vacuolisation (30 Gy) passed over into lipomatosis (46 Gy) and necrosis (60 Gy) in the parotid and mandibular glands. Six months after irradiation treatment, the chronic histomorphological damage corresponded to stage II according to Seifert. The corresponding loss in gland function was 13% (16 Gy); 26% (30 Gy); 57% (46 Gy); 75% (60 Gy) and 66.5% (6 months post irradiation).

CONCLUSION

This animal model demonstrates the correlation between histomorphological and scintigraphic findings.

摘要

引言

本研究的目的是将分次放疗期间唾液腺的结构、组织形态学损伤与闪烁扫描结果相关联。

方法

对27只WAG/RijH大鼠的头颈部区域用钴-60γ射线（60 Gy/30次/6周）进行照射。植入一个端口系统，并在照射的不同阶段（0、16、30、46、60 Gy以及照射后6个月）注射高锝[99mTc]酸盐。

结果

给予16 Gy照射后，唾液腺出现细胞内和细胞外水肿。腮腺和下颌下腺的渐进性空泡化（30 Gy）发展为脂肪化生（46 Gy）和坏死（60 Gy）。照射治疗6个月后，根据Seifert标准，慢性组织形态学损伤相当于II期。相应的腺体功能丧失分别为13%（16 Gy）；26%（30 Gy）；57%（46 Gy）；75%（60 Gy）和66.5%（照射后6个月）。