Sagowski C, Wenzel S, Jenicke L, Bohuslavizki K H, Kehrl W, Zywietz F, Roeser K
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg.
HNO. 2002 Sep;50(9):822-8. doi: 10.1007/s00106-001-0595-3.
Clinical studies show that amifostine can reduce xerostomia and mucositis during radiotherapy of head and neck cancers. The aim of this study was to evaluate the radioprotective potency of amifostine with respect to late toxicity of salivary glands of rats. The head-neck-area of 8 male WAG/RijH rats (295 +/- 7 g) were irradiated with 60Co-gamma-rays (60 Gy/30 f/6 weeks). Amifostine (250 mg/m2 body surface) was applied via a venous port 15 min before each irradiation. Rats of a control group were irradiated with the same schedule with equal volumes of physiological saline. The morphological and sialoscintigraphical findings clearly demonstrate that amifostine has a remarkable cytoprotective effect on the late toxicity of irradiated salivary glands.
临床研究表明，氨磷汀可减轻头颈部癌症放疗期间的口干症和粘膜炎。本研究的目的是评估氨磷汀对大鼠唾液腺晚期毒性的辐射防护效力。8只雄性WAG/RijH大鼠（体重295±7克）的头颈部区域接受60Co-γ射线照射（60 Gy/30次/6周）。每次照射前15分钟通过静脉端口给予氨磷汀（250毫克/平方米体表）。对照组大鼠按相同方案接受等量生理盐水照射。形态学和唾液腺闪烁造影结果清楚地表明，氨磷汀对受照射唾液腺的晚期毒性具有显著的细胞保护作用。
