Morino M, Ichinose T, Terakawa Y, Haba T, Wakasa K, Ohata K, Hara M
Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Acta Neurochir (Wien). 2004 Jan;146(1):59-63; discussion 63. doi: 10.1007/s00701-003-0162-7. Epub 2003 Dec 9.
We report a 36-year-old woman, who had previously undergone anterior temporal lobectomy for intractable temporal lobe seizures; fifteen months later, magnetic resonance (MR) images showed a space-occupying lesion in the temporal lobectomy cavity. After a second operation, a histopathological examination showed a grade III astrocytoma. The fortuitous co-occurrence of temporal lobe epilepsy and a tumour was suspected, but histopathological and immunohistochemical examination of original resected temporal lobe parenchyma did not show evidence of neoplasm. The patient had not undergone postoperative radiotherapy and had not experienced viral infections. We propose that two factors possibly associated with the development of glioma were chemical exposure from anticonvulsant agents and trauma from resection of the anterior temporal lobe during initial surgery.
我们报告了一名36岁女性，她此前因顽固性颞叶癫痫接受了前颞叶切除术；15个月后，磁共振（MR）图像显示在颞叶切除腔内有一个占位性病变。二次手术后，组织病理学检查显示为III级星形细胞瘤。怀疑颞叶癫痫与肿瘤偶然同时发生，但对最初切除的颞叶实质进行的组织病理学和免疫组织化学检查未发现肿瘤证据。该患者未接受术后放疗，也未经历病毒感染。我们认为，可能与胶质瘤发生相关的两个因素是抗惊厥药物的化学暴露以及初次手术时前颞叶切除所致的创伤。
