Ashley K D, Herndon D N, Traber L D, Traber D L, Deubel-Ashley K, Stothert J C, Kramer G C
Shriners Burns Institute, University of Texas Medical Branch, Galveston 77555-0749.
J Appl Physiol (1985). 1992 Nov;73(5):1996-2003. doi: 10.1152/jappl.1992.73.5.1996.
Discrepancies exist between experimental measurements of the systemic blood flow to sheep lung by use of microsphere techniques and flow probes on the bronchial artery. In these studies, we simultaneously measured the blood flow through the bronchial artery, using a transit time flow probe, and the systemic blood flow to left lung, using radioactive microspheres. All measurements were made on conscious sheep previously prepared with chronic catheterizations of the left atrium, aorta, and vena cava and a flow probe around the bronchial artery. Inflatable occluder cuffs were placed around the pulmonary and bronchoesophageal arteries. Bronchial artery blood flow in six sheep was 25.3 +/- 5.2 ml/min or 0.4% of the cardiac output. Systemic blood flow to left lung, measured with microspheres, was 54.1 +/- 14.2 ml/min. Calculated systemic blood flow to that portion of sheep lung perfused by the bronchial artery was 127.6 +/- 35.3 ml/min or 1.9% of cardiac output. Occlusion of the bronchoesophageal artery reduced bronchial artery flow to near zero, whereas total systemic blood to the lung was reduced by only 55%. Blood flow to the intraparenchymal cartilaginous airways was reduced 60-90% after occlusion of the bronchoesophageal artery. Sheep, like most mammals, have multiple and complex systemic arterial inputs to the lungs. We conclude that multiple branches of the bronchoesophageal artery provide most but not all of the systemic blood flow to the intraparenchymal cartilaginous airways but that over one-half of the total systemic blood flow to sheep lung comes from sources other than the common bronchial artery.
使用微球技术对绵羊肺的体循环血流量进行实验测量与使用流量探头测量支气管动脉血流量之间存在差异。在这些研究中，我们同时使用通过时间流量探头测量通过支气管动脉的血流量，并使用放射性微球测量左肺的体循环血流量。所有测量均在先前已进行左心房、主动脉和腔静脉慢性插管以及在支气管动脉周围放置流量探头的清醒绵羊身上进行。在肺动脉和支气管食管动脉周围放置可充气阻塞袖带。六只绵羊的支气管动脉血流量为25.3±5.2毫升/分钟，占心输出量的0.4%。用微球测量的左肺体循环血流量为54.1±14.2毫升/分钟。计算得出，由支气管动脉灌注的绵羊肺该部分的体循环血流量为127.6±35.3毫升/分钟，占心输出量的1.9%。阻塞支气管食管动脉可使支气管动脉血流量降至接近零，而肺的总体循环血流量仅减少55%。阻塞支气管食管动脉后，实质内软骨气道的血流量减少60 - 90%。与大多数哺乳动物一样，绵羊的肺有多个复杂的体循环动脉供血。我们得出结论，支气管食管动脉的多个分支为实质内软骨气道提供了大部分但并非全部的体循环血流量，但绵羊肺总体循环血流量的一半以上来自于除常见支气管动脉以外的其他来源。
