Degradation of target protein in living cells by small-molecule proteolysis inducer.
作者信息
Zhang Dong, Baek Sun Hee, Ho Abby, Kim Kyungbo
机构信息
University of Kentucky, Pharmaceutical Sciences, College of Pharmacy, 907 Rose Street, Lexington, KY 40536-0082, USA.
出版信息
Bioorg Med Chem Lett. 2004 Feb 9;14(3):645-8. doi: 10.1016/j.bmcl.2003.11.042.
PMID:14741260
Abstract
Ubiquitin-dependent proteolysis of cellular proteins is one of the major pathways to regulate protein function posttranslationally. Here we demonstrate a potentially general method of degrading any targeted proteins by the ubiquitin-dependent proteolysis in living cells, using small-molecule proteolysis inducer (SMPI).
摘要
Zotero 插件