Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists.

作者信息

Gfesser Gregory A, Zhang Henry, Dinges Jurgen, Fox Gerard B, Pan Jia Bao, Esbenshade Timothy A, Yao Betty B, Witte David, Miller Thomas R, Kang Chae-Hee, Krueger Kathy M, Bennani Youssef L, Hancock Arthur A, Faghih Ramin

机构信息

Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA.

出版信息

Bioorg Med Chem Lett. 2004 Feb 9;14(3):673-6. doi: 10.1016/j.bmcl.2003.11.038.

DOI:10.1016/j.bmcl.2003.11.038

PMID:14741266

Abstract

Further SAR studies on novel histamine H(3) receptor antagonists are presented. Compound 14bb is a potent antagonist of both the rat cortical and human clone receptors, and is demonstrated to act functionally as an antagonist in an in vivo mouse dipsogenia model.

摘要