Munin Michael C, Navalgund Brinda K, Levitt Donna A, Breisinger Terry P, Zafonte Ross D
Department of Physical Medicine & Rehabilitation, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Brain Inj. 2004 Apr;18(4):403-7. doi: 10.1080/02699050310001617334.
To determine if the finger flexor mapping technique is useful in the reduction of spasticity when injecting neurotoxin within the flexor digitorum superficialis muscle.
Case series of consecutive persons with acquired brain injury with upper limb spasticity.
The flexor digitorum superficialis mapping technique was used to determine the optimal location for botulinum toxin A insertion into each belly of the flexor digitorum superficialis. Modified Ashworth Scale (MAS) ratings were recorded pre- and post-flexor digitorum superficialis injection from 17 patients (18 limbs) with upper limb spasticity.
The pre-injection mean MAS score was 3.0 +/- 0.7 and the post-injection mean MAS score was 1.5 +/- 0.9 for this cohort. Using the Wilcoxon matched pairs signed rank test, the mean MAS finger flexor scores decreased significantly ( p < 0.05). No adverse events were noted with the procedure.
This novel technique appears to be feasible and effective for placement of botulinum toxin in the treatment of finger flexor spasticity. Further studies are warranted to compare this method of administration with other injection approaches for the treatment of finger flexor spasticity.
确定在指浅屈肌内注射神经毒素时，手指屈肌定位技术是否有助于减轻痉挛。
对连续性获得性脑损伤伴上肢痉挛患者的病例系列研究。
采用指浅屈肌定位技术确定A型肉毒杆菌毒素注入指浅屈肌各肌腹的最佳位置。记录了17例（18条肢体）上肢痉挛患者在指浅屈肌注射前后的改良Ashworth量表（MAS）评分。
该队列患者注射前MAS平均评分为3.0±0.7，注射后平均评分为1.5±0.9。采用Wilcoxon配对符号秩检验，MAS手指屈肌平均评分显著降低（p<0.05）。该操作未观察到不良事件。
这种新技术在A型肉毒杆菌毒素注射治疗手指屈肌痉挛方面似乎可行且有效。有必要进一步开展研究，将这种给药方法与治疗手指屈肌痉挛的其他注射方法进行比较。
