Yu Feng, Dong Yu-li, Zu Zhi-jiang, Zhan Xiao-dong, Shu Ji-hong, Yang Jia-shu, Han Guang-sheng, Lu Ling-chuan, Zhang Kai, Sun Hui-juan, Ren Ke-jie
Department of Otorhinolaryngology, Affiliated Hospital of Bengbu, Medical University, Bengbu 233004, China.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 2003 Aug;38(4):295-9.
To investigate the preservation of laryngeal function for the patients with hypopharyngeal cancer.
Two hundred and ninety-three cases of hypopharyngeal cancer with surgical management were reviewed retrospectively, and 222 cases were originated from pyriform sinus, 13 from post-cricoid, and 21 from posterior pharyngeal wall. Radiotherapy (37 cases), operation only (56 cases) and the combined treatment (operation plus radiation or chemotherapy, 200 cases) were adopted. 159 cases were treated with function preserved laryngectomy and 97 with total laryngectomy.
The 5 year survival rates of patient with laryngeal function preserved and no laryngeal function preserved were 51.3%, 47.6% (for stage III); 40.4%, 43.3% (for stage IV), respectively. There were no significant differences in 5-year survival between the functionally preserved group and no functioned group (P > 0.05). The analysis of survival rates revealed a significant difference between combined therapy and radiotherapy.
There is no significant difference between the survive rates of function preserved and non-preserved groups. Conservation laryngectomy improves the quality of patient's life, and combined therapy is the best choice for hypopharyngeal cancer.
探讨下咽癌患者喉功能的保留情况。
回顾性分析293例行手术治疗的下咽癌患者，其中222例起源于梨状窝，13例起源于环状软骨后，21例起源于下咽后壁。采用放射治疗（37例）、单纯手术（56例）及综合治疗（手术加放疗或化疗，200例）。159例行保留喉功能的喉切除术，97例行全喉切除术。
保留喉功能和未保留喉功能患者的5年生存率分别为：Ⅲ期51.3%、47.6%；Ⅳ期40.4%、43.3%。保留功能组与未保留功能组5年生存率差异无统计学意义（P>0.05）。生存率分析显示综合治疗与放射治疗之间存在显著差异。
保留功能组与未保留功能组的生存率差异无统计学意义。保留喉功能的喉切除术可提高患者生活质量，综合治疗是下咽癌的最佳选择。
