Dzhagatspanian I A, Paronikian R G, Nazarian I M
Laboratory of Psychopharmacology, Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of Armenia, prosp. Azatutyan 26, Yerevan, 375001 Armenia.
Eksp Klin Farmakol. 2003 Nov-Dec;66(6):20-3.
Investigation of the psychotropic spectrum of phenobarbital, diphenin, milontin, pufemide, sodium valproate (depakine), and diazeparn showed that, besides antagonism with the corazole and electroshock effects, all these drugs prevented to a considerable degree the kindling seizures in rats on a "tonsil swing" (chronic electroencephalographic partial epilepsy) model. The mechanism of this effect probably involves exciting amino acids. All anticonvulsants except for diazepam also restored memory in experimental animals with retrograde electroshock amnesia. The administration of diazepam, diphenin, and sodium valproate to rats with kindling convulsions led to activation of the spontaneous horizontal motions in the open-field test, which can be explained by the presence of antianxiety component in the drug action.
对苯巴比妥、苯妥英、乙琥胺、丙戊酸钠（德巴金）和地西泮的精神药物谱研究表明，除了与可拉唑和电休克效应存在拮抗作用外，所有这些药物在“扁桃体摆动”（慢性脑电图部分性癫痫）模型中都能在相当程度上预防大鼠的点燃性癫痫发作。这种效应的机制可能涉及兴奋性氨基酸。除地西泮外，所有抗惊厥药还能恢复患有逆行性电休克失忆症的实验动物的记忆。给患有点燃性惊厥的大鼠注射地西泮、苯妥英和丙戊酸钠会导致旷场试验中自发水平运动的激活，这可以用药物作用中存在抗焦虑成分来解释。
