Isaksson Marléne, Bruze Magnus
Department of Occupational and Environmental Dermatology, Malmö University Hospital, Malmo, Sweden.
Am J Contact Dermat. 2003 Sep;14(3):154-6. doi: 10.2310/6620.2003.6169.
Patch-test sensitization may be suspected when a flare-up is seen at a test site at least 10 days after the test application. We describe two patients allergic to budesonide who were only diagnosed at patch-test readings on day 10 and day 13, respectively. The patients were patch-tested to a standard series including two corticosteroid mixes and their three constituents in petrolatum, namely, budesonide, tixocortol pivalate, and hydrocortisone-17-butyrate, at differing concentrations. In both patients, positive reactions to the mixes were seen on day 6 or day 7, but positive reactions to the budesonide preparations at 0.1% and 0.002% were not seen on the first or second ordinary reading day, day 3 or 4, and day 6 or 7, but no positive reactions to both budesonide preparations were seen on day 10 and on day 13, respectively. Not all late patch-test reactions represent patch-test sensitization, at least not to budesonide.
当在试验敷用后至少10天在试验部位出现皮疹时，可能怀疑是斑贴试验致敏。我们描述了两名对布地奈德过敏的患者，他们分别在第10天和第13天的斑贴试验读数时才被诊断出来。对这两名患者进行了斑贴试验，使用的是一个标准系列，包括两种皮质类固醇混合物及其在凡士林里的三种成分，即布地奈德、匹伐酸替可的松和丁酸氢化可的松-17，浓度各不相同。在这两名患者中，在第6天或第7天对混合物出现了阳性反应，但在第1次或第2次常规读数日，即第3或4天以及第6或7天，对0.1%和0.002%的布地奈德制剂未出现阳性反应，而分别在第10天和第13天对两种布地奈德制剂均未出现阳性反应。并非所有迟发性斑贴试验反应都代表斑贴试验致敏，至少对布地奈德而言并非如此。
