Flier Jeffrey S
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Cell. 2004 Jan 23;116(2):337-50. doi: 10.1016/s0092-8674(03)01081-x.
The worldwide prevalence of obesity is increasing at an alarming rate, with major adverse consequences for human health. This "obesity epidemic" is paralleled by a rapid and substantive increase in our understanding of molecular pathways and physiologic systems underlying the regulation of energy balance. While efforts to address the environmental factors that are responsible for the recent "epidemic" must continue, new molecular and physiologic insights into this system offer exciting possibilities for future development of successful therapies.
全球肥胖症患病率正以惊人的速度上升，对人类健康造成重大不良后果。这种“肥胖流行”伴随着我们对能量平衡调节背后的分子途径和生理系统的理解迅速而实质性地增加。虽然解决导致近期“流行”的环境因素的努力必须继续，但对该系统的新分子和生理见解为未来成功疗法的开发提供了令人兴奋的可能性。
