阿尔茨海默病中朊病毒（PrP）基因和类朊病毒蛋白（多普蛋白）基因内的多态性。

Polymorphisms within the prion (PrP) and prion-like protein (Doppel) genes in AD.

作者信息

Golanska E, Hulas-Bigoszewska K, Rutkiewicz E, Styczynska M, Peplonska B, Barcikowska M, Bratosiewicz-Wasik J, Liberski P P

机构信息

Department of Molecular Pathology and Neuropathology, Medical University of Lodz, Poland.

出版信息

Neurology. 2004 Jan 27;62(2):313-5. doi: 10.1212/01.wnl.0000103290.74549.dc.

DOI:10.1212/01.wnl.0000103290.74549.dc

PMID:14745079

Abstract

The authors present a study on the association of PRNP and PRND gene polymorphisms with the occurrence and age at onset of Alzheimer's disease (AD). DNA from 79 Polish patients with probable AD and 107 healthy control subjects was studied. The PRNP codon 129 homozygosity seemed to be associated with the occurrence of AD: In AD patients, the percentage of Val/Val and Met/Met genotypes was higher than in the control subjects. A significant difference appeared also between early-onset (<70 years) and late-onset (> or = 70 years) AD patients in the PRND genotypes.

摘要

作者们展示了一项关于PRNP和PRND基因多态性与阿尔茨海默病（AD）的发生及发病年龄之间关联的研究。对79名波兰可能患有AD的患者以及107名健康对照者的DNA进行了研究。PRNP密码子129纯合性似乎与AD的发生有关：在AD患者中，Val/Val和Met/Met基因型的百分比高于对照者。PRND基因型在早发型（<70岁）和晚发型（≥70岁）AD患者之间也出现了显著差异。