Polymorphism at codon 129 of the prion protein gene is not associated with sporadic AD.
作者信息
Combarros O, Sánchez-Guerra M, Llorca J, Alvarez-Arcaya A, Berciano J, Peña N, Fernández-Viadero C
机构信息
Service of Neurology, University Hospital Marqués de Valdecilla, Santander, Spain.
出版信息
Neurology. 2000 Aug 22;55(4):593-5. doi: 10.1212/wnl.55.4.593.
PMID:10953203
Abstract
An association between cognitive performance in elderly people and variability in the codon 129 of the prion protein gene (PRNP) has been recently described. The authors analyzed this polymorphism in 278 sporadic AD patients and 268 cognitively normal control subjects. Analyses stratifying by APOE genotype, age, and gender failed to reveal any association between homozygosity for the 129 PRNP methionine or valine alleles and AD.
摘要
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