Kanematsu Takashi, Terunuma Miho, Goto Hidefumi, Kuratani Akiko, Hirata Masato
Cellular and Molecular Biochemistry, Faculty of Dental Science and Station for Collaborative Research, Kyushu University, Fukuoka, Japan.
Nihon Yakurigaku Zasshi. 2004 Feb;123(2):105-12. doi: 10.1254/fpj.123.105.
Gamma-aminobutyric acid(A) (GABA(A)) receptors mediate most of the fast inhibitory neurotransmission in the central nervous system. These ligand-gated ion channels are crucial in the control of cell and network activity. Therefore, modulating their function or cell surface stability will have major consequences for neuronal excitation. This review highlights recent findings on the regulation of GABA(A)-receptor expression and function, focusing on the mechanisms of sorting, targeting, synaptic clustering, and endocytic events of GABA(A) receptors, all which are regulated by their associated proteins. Now these topics are an area of active interest in studies on inhibitory neurotransmission.
γ-氨基丁酸A（GABA(A)）受体介导中枢神经系统中大部分快速抑制性神经传递。这些配体门控离子通道在细胞和网络活动的控制中至关重要。因此，调节它们的功能或细胞表面稳定性将对神经元兴奋产生重大影响。本综述重点介绍了关于GABA(A)受体表达和功能调节的最新发现，着重于GABA(A)受体的分选、靶向、突触聚集和内吞事件的机制，所有这些均受其相关蛋白的调控。目前，这些主题是抑制性神经传递研究中一个备受关注的领域。
