Paydas Semra
Department of Oncology, Faculty of Medicine, Cukurova University, Adana, Turkey.
Hematol J. 2004;5(1):81-3. doi: 10.1038/sj.thj.6200339.
Autoimmune disorders are frequent in chronic lymphocytic leukemia (CLL). Some drugs such as fludarabine may increase the risk of these phenomena and may even be fatal. The management of autoimmune disorders is not standard and corticosteroid is the most frequently used drug in these situations. Here, a case with CLL and severe autoimmune hemolytic anemia associated with fludarabine and successful treatment by rituximab has been reported.
自身免疫性疾病在慢性淋巴细胞白血病（CLL）中很常见。一些药物，如氟达拉滨，可能会增加这些现象的风险，甚至可能是致命的。自身免疫性疾病的管理并不规范，皮质类固醇是这些情况下最常用的药物。在此，报告了一例CLL患者伴有与氟达拉滨相关的严重自身免疫性溶血性贫血，并通过利妥昔单抗成功治疗的病例。
