Jaye Assan, Sarge-Njie Ramu, Schim van der Loeff Maarten, Todd Jim, Alabi Abraham, Sabally Shehu, Corrah Tumani, Whittle Hilton
Medical Research Council Laboratories, Banjul, The Gambia.
J Infect Dis. 2004 Feb 1;189(3):498-505. doi: 10.1086/381185. Epub 2004 Jan 21.
Fewer people infected with human immunodeficiency virus (HIV) type 2 progress to acquired immunodeficiency syndrome, compared with those infected with HIV-1. To understand the immune mechanisms leading to slow progression in HIV-2 infection, cell-mediated immune responses were compared between the 2 infections in asymptomatic subjects with a CD4 cell count > or =20%. Interferon- gamma release from T lymphocytes and the cytotoxicity of CD8+ T lymphocytes were measured by ELISPOT and 51Cr release assays. The level of responses and the proportion of responders were similar in the 2 infections, despite a 20-fold difference in their geometric mean plasma virus loads. The proliferation of CD4+ T helper cells, which was evaluated by thymidine incorporation, was not different between the 2 infections. Contrary to widely held views, our results suggest that nonprogression in HIV-2 infection may not be due to more vigorous immune responses.
与感染HIV - 1的人相比，感染2型人类免疫缺陷病毒（HIV）的人发展为获得性免疫缺陷综合征的人数较少。为了解导致HIV - 2感染进展缓慢的免疫机制，对CD4细胞计数≥20%的无症状受试者的这两种感染之间的细胞介导免疫反应进行了比较。通过ELISPOT和51Cr释放试验测量T淋巴细胞释放的干扰素 - γ以及CD8 + T淋巴细胞的细胞毒性。尽管两种感染的几何平均血浆病毒载量相差20倍，但两种感染的反应水平和反应者比例相似。通过胸苷掺入评估的CD4 + T辅助细胞的增殖在两种感染之间没有差异。与广泛持有的观点相反，我们的结果表明，HIV - 2感染不进展可能不是由于更强烈的免疫反应。
