James William H
Galton Laboratory, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, United Kingdom.
Birth Defects Res A Clin Mol Teratol. 2004 Jan;70(1):37-9. doi: 10.1002/bdra.10097.
It is rather well established that the causal antecedents of pyloric stenosis (PS) contain both genetic and environmental factors. However, in spite of substantial quantities of epidemiological data, no widespread environmental causal agent has yet been established. There have been recent extensions of our knowledge of the endocrine consequences of fetal growth restriction and of the endocrine determinants of sex ratio. It seemed worth reviewing the epidemiological data on PS in the light of these new developments to see whether this would provide a basis for a plausible hypothesis on these suspected environmental causes of PS.
The search terms "pyloric stenosis" and ("epidemiology" or "risk factors") were combined on the Ovid Medline data base for the years 1966 onwards. The data from the resulting papers were augmented by notes occasioned by almost daily reading at the Library of the Royal Society of Medicine (London) for the past 25 years. (Electronic data retrieval systems do not access incidentally recorded data such as sib sex ratios).
It is hypothesized that high intrauterine and early postnatal androgen levels constitute an environmental cause of PS.
幽门狭窄（PS）的病因包含遗传和环境因素，这一点已得到充分证实。然而，尽管有大量的流行病学数据，但尚未确定广泛存在的环境致病因素。最近，我们对胎儿生长受限的内分泌后果以及性别比例的内分泌决定因素的认识有所扩展。鉴于这些新进展，似乎有必要回顾一下PS的流行病学数据，看看这是否能为关于PS这些可疑环境病因的合理假设提供依据。
在Ovid Medline数据库中，对1966年起的文献检索词“幽门狭窄”和（“流行病学”或“危险因素”）进行组合检索。过去25年在（伦敦）皇家医学学会图书馆几乎每日阅读所做的笔记，补充了检索所得论文的数据。（电子数据检索系统无法获取诸如同胞性别比例等偶然记录的数据）。
据推测，子宫内和出生后早期雄激素水平高是PS的一个环境病因。
