Chou Shih-Yu, Kao Shu-Ching, Hsu Wen-Ming
Clin Exp Ophthalmol. 2004 Feb;32(1):106-8. doi: 10.1046/j.1442-9071.2004.00770.x.
A 43-year-old man presented suffering from decreasing vision in both eyes for 3 months. The patient's visual acuity was 6/20 (non-corrected) in the right eye and 6/10 (-1.75/-1.00 x 91) in the left. Ocular examination of both eyes revealed anterior subcapsular opacities of both lenses with the right eye being more severe than the left. He had been taking finasteride (Propecia; Merck, Sharp and Dohme) at 1 mg/day for 3 years to treat early stage of androgenic alopecia. It was highly suspected that finasteride was associated with the anterior subcapsular opacity on the lens, and the patient therefore discontinued use of finasteride. He underwent uneventful cataract extraction surgery and intraocular lens implantation of the right eye. One month after cataract surgery in the right eye, the best-corrected visual acuity was right 6/6 (-1.25) and left 6/10 (-2.00/-0.50 x 100). To the best of the authors' knowledge, this is the first reported case of Propecia-associated cataract.
一名43岁男性因双眼视力下降3个月前来就诊。患者右眼视力为6/20（未矫正），左眼视力为6/10（-1.75/-1.00×91）。双眼眼部检查均发现晶状体前囊下混浊，右眼比左眼更严重。他服用非那雄胺（保法止；默克公司）1毫克/天，用于治疗早期雄激素性脱发，已服用3年。高度怀疑非那雄胺与晶状体前囊下混浊有关，因此患者停用了非那雄胺。他接受了右眼白内障摘除术及人工晶状体植入术，手术过程顺利。右眼白内障手术后1个月，最佳矫正视力右眼为6/6（-1.25），左眼为6/10（-2.00/-0.50×100）。据作者所知，这是首例报道的保法止相关性白内障病例。
