Hviid Lars, Staalsoe Trine
Centre for Medical Parasitology, Department of Infectious Diseases, Rigshospitalet, 2100, Copenhagen Ø, Denmark.
Trends Parasitol. 2004 Feb;20(2):66-72. doi: 10.1016/j.pt.2003.11.009.
Newborn infants in endemic areas are markedly resistant to Plasmodium falciparum malaria. Consequently, severe disease is rare during the first few months of life, and infections tend to be low density and relatively asymptomatic during this period. Although this is generally ascribed to passively transferred immunity, attempts to identify the targets and mechanisms of this protection have been unsuccessful. The implications of the hypothesis that the progression from resistance through susceptibility and back to resistance during infancy and early childhood reflects the gradual acquisition of IgG to variant surface antigens (VSAs), while protection from maternal VSA-specific IgG steadily fades, are discussed here.
疟疾流行地区的新生儿对恶性疟原虫具有显著抗性。因此，在生命的最初几个月里，严重疾病较为罕见，在此期间感染往往密度较低且相对无症状。尽管这通常归因于被动转移的免疫力，但确定这种保护的靶点和机制的尝试并未成功。本文讨论了一种假说的意义，即在婴儿期和幼儿期从抗性到易感性再回到抗性的过程反映了针对变异表面抗原（VSA）的IgG的逐渐获得，而来自母体VSA特异性IgG的保护作用则稳步减弱。
