Moda Y
Department of Physiology, Kawasaki Medical School.
Nihon Hinyokika Gakkai Zasshi. 1992 Dec;83(12):2005-14. doi: 10.5980/jpnjurol1989.83.2005.
(1) The study was performed to elucidate the effects of afferent vagal stimulation and distension of the digestive tract on the micturition reflex in 21 acute decerebrate dogs immobilized with gallamine. Electrical stimulation of the central cut end of the cervical vagus nerve with high voltage (17.5-25 V) and moderate frequency (10-50 Hz) elicited in most cases inhibition of the periodic bladder contractions and of outflows of the pelvic vesical branch which were induced by a sustained intravesical pressure of 10-15 cmH2O. Distension of the thoracic esophagus, the stomach, and the duodenum also induced inhibition of the bladder contractions and of the pelvic outflow to the bladder. Such inhibitions were abolished after bilateral cervical vagotomies except a few cases of distension of the duodenum. (2) Another series of experiments were undertaken to clear the effect of afferent vagal stimulation on the electrical activity of the pontine micturition center in 10 acute decerebrate dogs. By means of an extracellular glass microelectrode method, unitary discharges synchronized with the grouping discharges in the pelvic vesical branch with a rhythm of 2.2-2.5 Hz were recorded from the pontine micturition center in the dorsolateral pontine tegmentum. Such a type of discharges was detected in 6 of 59 units which discharged by afferent stimulation of the pelvic vesical branch. This type of discharges was inhibited by afferent vagal stimulation at the supradiaphragmatic level. From these results, it may be concluded that the afferent pathway of the bladder relaxation reflex induced by distension of the upper digestive tract is mainly involved in the vagal nerves, but in some cases of the strong distension of the duodenum, the pathway is in splanchnic nerves, and that inhibition of the bladder contraction after stimulation of vagal nerve is induced by suppression of the pontine micturition centers.
(1) 本研究旨在阐明在21只使用三碘季铵酚固定的急性去大脑犬中，传入性迷走神经刺激和消化道扩张对排尿反射的影响。用高压（17.5 - 25 V）和中等频率（10 - 50 Hz）电刺激颈迷走神经的中枢切断端，在大多数情况下可抑制由10 - 15 cmH₂O的持续膀胱内压诱导的周期性膀胱收缩和盆腔膀胱分支的流出。胸段食管、胃和十二指肠的扩张也可诱导膀胱收缩和盆腔向膀胱的流出受到抑制。除少数十二指肠扩张的情况外，双侧颈迷走神经切断术后这种抑制作用消失。(2) 另一系列实验旨在明确在10只急性去大脑犬中传入性迷走神经刺激对脑桥排尿中枢电活动的影响。通过细胞外玻璃微电极方法，从脑桥背外侧被盖的脑桥排尿中枢记录到与盆腔膀胱分支中频率为2.2 - 2.5 Hz的成组放电同步的单位放电。在由盆腔膀胱分支的传入刺激引发放电的59个单位中的6个中检测到了这种类型的放电。这种类型的放电在膈上水平受到传入性迷走神经刺激的抑制。从这些结果可以得出结论，上消化道扩张诱导的膀胱舒张反射的传入通路主要涉及迷走神经，但在十二指肠强烈扩张的某些情况下，该通路存在于内脏神经中，并且迷走神经刺激后膀胱收缩受到抑制是由脑桥排尿中枢的抑制引起的。
