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疟原虫表面蛋白1——一种多功能蛋白?

STEVOR--a multifunctional protein?

作者信息

Blythe J E, Surentheran T, Preiser P R

机构信息

Division of Parasitology, The National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

出版信息

Mol Biochem Parasitol. 2004 Mar;134(1):11-5. doi: 10.1016/j.molbiopara.2003.09.011.

Abstract

The stevor multigene family is the third largest identified in Plasmodium falciparum. Its members have the potential to be involved in antigenic variation and virulence by analogy with the var and rif multigene families. This review highlights recent studies of stevor transcription and expression which show that stevor is distinct from both the var and rif multigene families. STEVOR is expressed during several stages of the lifecycle, and thus may contribute significantly to the long term survival of the parasite.

摘要

疟原虫史氏变异抗原多基因家族是在恶性疟原虫中鉴定出的第三大多基因家族。类比于var和rif多基因家族,其成员有可能参与抗原变异和毒力作用。本综述重点介绍了近期关于史氏变异抗原转录和表达的研究,这些研究表明史氏变异抗原多基因家族不同于var和rif多基因家族。史氏变异抗原在疟原虫生命周期的多个阶段表达,因此可能对疟原虫的长期存活有显著贡献。

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