Nogueira P A, Wunderlich G, Pereira da Silva L H
Centro de Pesquisa em Medicina Tropical, Porto Velho, Rond nia, Brazil.
Res Microbiol. 2001 Mar;152(2):141-7. doi: 10.1016/s0923-2508(01)01184-6.
Cytoadhesion of parasitized red blood cells (PRBCs) to vascular endothelial cells (sequestration) and binding of unparasitized RBCs to PRBCs (rosetting) are virulence factors of Plasmodium falciparum, the species responsible for lethal human malaria. Variant antigens involved in both phenomena have been identified as products of the multicopy var gene family. In this review, progress in the understanding of molecular mechanisms of sequestration is summarized, in particular, concerning the structure of var gene products related to specificity of binding to endothelial receptors, and the origin of var gene diversity.
被寄生的红细胞（PRBCs）与血管内皮细胞的细胞黏附（隔离）以及未被寄生的红细胞与PRBCs的结合（花结形成）是恶性疟原虫的致病因素，该物种是导致人类致命疟疾的罪魁祸首。参与这两种现象的变异抗原已被确定为多拷贝var基因家族的产物。在这篇综述中，总结了对隔离分子机制理解的进展，特别是关于与内皮受体结合特异性相关的var基因产物的结构，以及var基因多样性的起源。
