Motomiya Y, Sasaki K, Maruyama Y, Arai K, Ozono S, Hirao Y, Okajima E, Uji Y, Okabe H
Department of Urology, Nara University School of Medicine.
Nihon Hinyokika Gakkai Zasshi. 1992 Dec;83(12):2085-9. doi: 10.5980/jpnjurol1989.83.2085.
Currently, urinary excretion of free gamma-carboxyglutamic acid (gamma-gla.), a terminal amino acid degraded from gamma-gla. containing protein including bone Gla. Estimated to be a more specific marker for bone metabolism and useful clinically rather than urinary excretion of hydroxyproline. In addition, serum levels of BGP have proved to be a significantly valuable indicator for bone metabolism, especially for process of bone formation, in recent studies. Therefore, we measured these parameters in 40 patients with idiopathic urinary calcium (Ca) stone and investigated bone metabolism in those patients. However, in majority of cases studied, urinary levels of gamma-gla. as well as that of hydroxyproline proved to be definite difference from that in healthy subjects (n = 12) and failed to suggest the presence of abnormality in bone turnover in the background of stone formation. Urinary excretion of hydroxyproline were 6.68 +/- 3.89 micrograms/mg.Cr in the patients and 6.95 +/- 3.08 micrograms/mg.Cr in healthy subjects. Urinary excretion of gamma-gla were 55.0 +/- 15.8 nmol/mg.Cr in the patients and 47.2 +/- 7.3 nmol/mg.Cr in healthy subjects.
目前，游离γ-羧基谷氨酸（γ-Gla.）的尿排泄量，γ-Gla.是一种从含γ-Gla.的蛋白质（包括骨钙素）降解而来的末端氨基酸。据估计，它是骨代谢更特异的标志物，在临床上比羟脯氨酸的尿排泄更有用。此外，在最近的研究中，骨钙素（BGP）的血清水平已被证明是骨代谢，尤其是骨形成过程的一个有显著价值的指标。因此，我们测定了40例特发性尿钙结石患者的这些参数，并对这些患者的骨代谢进行了研究。然而，在大多数研究病例中，γ-Gla.以及羟脯氨酸的尿水平与健康受试者（n = 12）相比有明显差异，未能提示结石形成背景下骨转换存在异常。患者的羟脯氨酸尿排泄量为6.68±3.89微克/毫克肌酐，健康受试者为6.95±3.08微克/毫克肌酐。患者的γ-Gla.尿排泄量为55.0±15.8纳摩尔/毫克肌酐，健康受试者为47.2±7.3纳摩尔/毫克肌酐。
