塌陷后二棕榈酰磷脂酰甘油单层膜恢复的静电屏障
Electrostatic barrier to recovery of dipalmitoylphosphatidylglycerol monolayers after collapse.
作者信息
Alig Tim F, Warriner Heidi E, Lee Lily, Zasadzinski Joseph A
机构信息
Department of Chemical Engineering, University of California, Santa Barbara, California 93106-5080, USA.
出版信息
Biophys J. 2004 Feb;86(2):897-904. doi: 10.1016/S0006-3495(04)74165-X.
Abstract
The reincorporation of lipids into monolayers at the air-water interface after collapse is important to the maintenance of low surface tensions on subsequent expansion and compression cycles. For single component, anionic dipalmitoylphosphatidylglycerol monolayers, the fraction of recovered lipid is proportional to the subphase ionic strength. The collapse mechanism and structure of the collapsed materials appear unchanged with ionic strength. A simple electrostatic barrier model shows that the fractional recovery depends exponentially on the Debye length; this is verified by experiment. This simple model suggests possible catalytic roles for the cationic lung surfactant specific proteins SP-B and SP-C that induce structural changes in the monolayer that may act as charge-neutralizing docking sites for surfactant in the subphase, leading to faster and more efficient recovery.
摘要
塌陷后脂质在气-水界面重新并入单分子层对于在随后的膨胀和压缩循环中维持低表面张力很重要。对于单组分阴离子二棕榈酰磷脂酰甘油单分子层，回收的脂质分数与亚相离子强度成正比。塌陷材料的塌陷机制和结构似乎随离子强度而不变。一个简单的静电屏障模型表明，分数回收率指数地取决于德拜长度；这已通过实验得到验证。这个简单模型表明阳离子肺表面活性剂特异性蛋白SP-B和SP-C可能具有催化作用，它们会诱导单分子层发生结构变化，这些变化可能充当亚相中表面活性剂的电荷中和对接位点，从而导致更快、更有效的回收。
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