O'Leary R, Hawkins K, Beazley J C S, Lansdown M R J, Hanby A M
School of Medicine, University of Leeds, Leeds, LS2 9NL, UK.
J Clin Pathol. 2004 Feb;57(2):193-5. doi: 10.1136/jcp.2003.12914.
To establish the relation between the amount of breast core needle biopsy (CNB) material examined and agreement between preoperative and postoperative histopathology parameters in invasive breast cancer.
The CNB and surgical specimen histopathology reports of 113 patients with invasive breast carcinoma were reviewed and the total amount of CNB material examined for each case was determined. Agreement was calculated for tumour type, grade, mitoses, nuclear pleomorphism, and tubule formation. Associations between the amount of CNB material and histopathology agreement before and after surgery were explored using binary logistic regression.
Tumour type and grade agreed in 65.4% and 61.6% of cases, respectively. The components used to calculate grade--nuclear pleomorphism (57.4%), mitoses (59.4%), and tubule formation (55.6%)--agreed slightly less frequently. The proportion of cases with preoperative and postoperative assessments that agreed did not depend on the number of cores collected or the total amount of material examined.
Neither tumour type and grade, nor the individual components used to calculate grade agreed consistently between the CNB and surgical specimen. The number of cores collected and the total amount of material reviewed by the pathologist does not influence the likelihood of agreement between preoperative and postoperative histopathology reports.
确定浸润性乳腺癌中乳腺粗针活检（CNB）所检查材料的数量与术前和术后组织病理学参数之间的关系。
回顾了113例浸润性乳腺癌患者的CNB和手术标本组织病理学报告，并确定了每例所检查的CNB材料总量。计算了肿瘤类型、分级、有丝分裂、核多形性和小管形成的一致性。使用二元逻辑回归探讨了CNB材料数量与手术前后组织病理学一致性之间的关联。
肿瘤类型和分级在65.4%和61.6%的病例中一致。用于计算分级的组成部分——核多形性（57.4%）、有丝分裂（59.4%）和小管形成（55.6%）——一致性稍低。术前和术后评估一致的病例比例不取决于采集的芯针数量或所检查材料的总量。
CNB与手术标本之间，肿瘤类型和分级，以及用于计算分级的各个组成部分均未始终保持一致。病理学家采集的芯针数量和所检查材料的总量并不影响术前和术后组织病理学报告一致的可能性。
