Barrueto Fermin, Howland Mary Ann, Hoffman Robert S, Nelson Lewis S
Division of Emergency Medicine, Department of Surgery, University of Maryland School of Medicine, 419 West Redwood Street, Suite 280, Baltimore, Maryland 21201, USA.
Vet Hum Toxicol. 2004 Feb;46(1):30-1.
Fentanyl patches create unique opportunities for use and abuse. Each patch contains 100-fold more drug than is stated on the label in order to create the gradient required to deliver the stated amount (ie 25-100 microg/h). Several methods of abuse of this analgesic have been reported, ranging from ingestion to inhalation to application of multiple patches to the skin. We report the unique case of a 21-y-old woman who steeped a fentanyl patch in a cup of hot water and then drank the mixture. Coma and hypoventilation resulted. The woman was resuscitated with naloxone i.v. and recovered without sequelae.
芬太尼透皮贴剂带来了独特的使用和滥用机会。每片贴剂所含药物比标签上标注的多100倍,以形成输送规定剂量(即25 - 100微克/小时)所需的梯度。据报道,这种镇痛药存在多种滥用方式,从口服到吸入,再到在皮肤上贴多个贴剂。我们报告了一例独特病例,一名21岁女性将一片芬太尼透皮贴剂浸泡在一杯热水中,然后喝下了混合液。结果导致昏迷和通气不足。该女性通过静脉注射纳洛酮得以复苏,且康复后无后遗症。